反应条件
Multi-step reaction with 7 steps 1: 1) NaOCH3, H2O, 2) AcOH / 1) MeOH, overnight, 2) benzene, H2O, 80 deg C2: 97 percent / benzene / 2 h / Heating3: 99 percent / H2 / 5percent Pd-C / acetic acid / 2844.3 Torr / Ambient temperature4: 81 percent / 5percent aq. KOH / 2 h / Heating5: 90 percent / methanesulfonic acid / 12 h / Ambient temperature6: 99 percent / NaBH4 / methanol; CH2Cl2 / 3 h / Ambient temperature7: 85 percent / KHSO4 / Heating
参考文献
Cannon; True; Long; Bhatnagar; Leonard; Flynn Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2210 - 2214