1-噁-6-氮杂螺[3.3]庚烷-6-羧酸叔丁酯合成路线 （共 3 条）
反应条件
1: trimethyl-oxo-sulfonium iodide With potassium tert-butylate in tert-butyl alcohol T=50°C; 1.5 h; 2: 3-oxo-azetidine-1-carboxylic acid tert-butyl ester in tert-butyl alcohol T=50°C; 48 h;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; NG, Pui, Yee; BLUM, Charles; MCPHERSON, Lauren; PERNI, Robert, B.; VU, Chi, B.; AHMED, Mohammed, Mahmood; DISCH, Jeremy, S.
Patent: WO2011/59839 A1, 2011 ;
Location in patent: Page/Page column 80-81 ;
WO 2011/059839 A1
反应条件
1: tert-butyl alcohol With potassium tert-butylate; trimethyl-oxo-sulfonium iodide T=50°C; 1.5 h; 2: 3-oxo-azetidine-1-carboxylic acid tert-butyl ester T=50°C; 48 h;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.
Patent: WO2013/59587 A1, 2013 ;
Location in patent: Page/Page column 214 ;
反应条件
1: trimethylsulfoxonium iodide With potassium tert-butylate in tert-butyl alcohol T=50°C; 1.5 h; Inert atmosphere; 2: 3-oxo-azetidine-1-carboxylic acid tert-butyl ester in tert-butyl alcohol T=50°C; 48 h; Inert atmosphere;
参考文献
Burkhard, Johannes A.; Guerot, Carine; Knust, Henner; Rogers-Evans, Mark; Carreira, Erick M.
Organic Letters, 2010 , vol. 12, # 9 p. 1944 - 1947
