5-羟基-1-甲基-3-三氟甲基-1H-吡唑合成路线 （共 8 条）
反应条件
hydrogenchloride in ethanol; water 48 h; Reflux;
参考文献
Hoffmann-La Roche Inc.; Alam, Muzaffar; Du Bois, Daisy Joe; Hawley, Ronald Charles; Bhagirath, Niala; Kennedy-Smith, Joshua; Wilhelm, Robert Stephen
Patent: US2013/158049 A1, 2013 ;
Location in patent: Paragraph 0143 ;
反应条件
1: in ethanol T=20 - 80°C; 15 h; 2: With sodium hydroxide in ethanol T=20°C; 1 h;
参考文献
KALYPSYS, INC.
Patent: WO2007/84868 A2, 2007 ;
Location in patent: Page/Page column 26 ;
WO 2007/084868 A2
反应条件
in water 2 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 27, # 2 p. 243 - 245
反应条件
in ethanol 24 h; Heating;
参考文献
Martins, Marcos A.P.; Pereira, Claudio M.P.; Zimmermann, Nilo E.K.; Cunico, Wilson; Moura, Sidnei; Beck, Paulo; Zanatta, Nilo; Bonacorso, Helio G.
Journal of Fluorine Chemistry, 2003 , vol. 123, # 2 p. 261 - 265
反应条件
in methanol; water 12 h;
参考文献
Journal of Fluorine Chemistry, , vol. 48, # 1 p. 123 - 131
参考文献
Journal of Heterocyclic Chemistry, , vol. 30, # 1 p. 49 - 54
反应条件
trichlorophosphate T=0 - 20°C; 1 h; Heating / reflux;
参考文献
KUMIAI CHEMICAL INDUSTRY CO., LTD.; IHARA CHEMICAL INDUSTRY CO., LTD.
Patent: EP1405853 A1, 2004 ;
Location in patent: Page 83-84 ;
反应条件
1.1: sodium hydroxide / water / 2.58 h / 24 °C
1.2: 16 h / 20 °C
1.3: 16 h / 14 - 20 °C
2.1: sodium hydroxide / acetonitrile / 1.67 h / 20 - 24 °C
2.2: 60.75 h / 5 - 20 °C
3.1: dihydrogen peroxide / Na2WO4·2H2O / acetic acid / 16.33 h / 20 - 34 °C
View Scheme
参考文献
BASF SE
Patent: US2012/264947 A1, 2012 ;
