4-氟-2-甲基-5-硝基苯酚合成路线 (共 5 条)
反应条件
ammonia in water T=20°C; 1 h;
参考文献
Zeneca Limited; Zeneca Pharma S.A.
Patent: US6809097 B1, 2004 ;
Location in patent: Page column 38-39 ;
US 6809097 B1
反应条件
sulfuric acid; nitric acid T=50°C; Nitration; Deacetylation; 2 h;
参考文献
Zeneca Limited
Patent: US6184225 B2, 2001 ;
反应条件
1: 86 percent / pyridine / dioxane / 0 - 20 °C 2: 90 percent / HNO3; H2SO4 / 0.5 h / 0 °C 3: 85 percent / BBr3 / CH2Cl2 / 18 h / 0 - 20 °C View Scheme
参考文献
Hennequin, Laurent F.; Thomas, Andrew P.; Johnstone, Craig; Stokes, Elaine S. E.; Ple, Patrick A.; Lohmann, Jean-Jacques M.; Ogilvie, Donald J.; Dukes, Mike; Wedge, Steve R.; Curwen, Jon O.; Kendrew, Jane; Lambert-Van Der Brempt, Christine
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5369 - 5389
反应条件
hydrogen; palladium 10 on activated carbon in methanol P=1551.49 Torr; 2 h;
参考文献
DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel, L.; PETILLO, Peter, A.; KAUFMAN, Michael, D.
Patent: WO2010/51373 A1, 2010 ;
Location in patent: Page/Page column 69-70 ;
WO 2010/051373 A1
参考文献
Zeneca Limited
Patent: US6184225 B2, 2001 ;