5-氨基-4-氟-2-甲基苯酚合成路线 （共 4 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol P=1551.49 Torr; 2 h;
参考文献
DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel, L.; PETILLO, Peter, A.; KAUFMAN, Michael, D.
Patent: WO2010/51373 A1, 2010 ;
Location in patent: Page/Page column 69-70 ;
WO 2010/051373 A1
参考文献
Zeneca Limited
Patent: US6184225 B2, 2001 ;
反应条件
1: 78 percent / aq. NaOH / 2 h / 0 °C 2: 22 percent / HNO3; H2SO4 / 2 h / 50 °C 3: 47 percent / Fe; FeSO4 / H2O / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 26 p. 5369 - 5389
反应条件
1: 22 percent / HNO3; H2SO4 / 2 h / 50 °C 2: 47 percent / Fe; FeSO4 / H2O / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 26 p. 5369 - 5389
