1-(2-甲基苯基)-4-甲基氨基-6-甲基-2,3-二氢吡咯并(3,2-c)喹啉合成路线 （共 4 条）
反应条件
methylamine in ethanol
参考文献
SmithKline Beckman Intercredit B.V.
Patent: US5051508 A1, 1991 ;
US 5051508 A
反应条件
in ethanol T=180°C; 24 h;
参考文献
Leach, Colin A.; Brown, Thomas H.; Ife, Robert J.; Keeling, David J.; Laing, Shiona M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1845 - 1852
反应条件
1: 237 g / 5 h / 195 °C 2: 2.) phosphoryl chloride / 1.) diphenyl ether, reflux, 7 h, 2.) reflux, 1.5 h 3: 71 percent / ethanol / 24 h / 180 °C View Scheme
参考文献
Leach, Colin A.; Brown, Thomas H.; Ife, Robert J.; Keeling, David J.; Laing, Shiona M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1845 - 1852
反应条件
1: 2.) phosphoryl chloride / 1.) diphenyl ether, reflux, 7 h, 2.) reflux, 1.5 h 2: 71 percent / ethanol / 24 h / 180 °C View Scheme
参考文献
Leach, Colin A.; Brown, Thomas H.; Ife, Robert J.; Keeling, David J.; Laing, Shiona M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1845 - 1852
