反应条件
1: ethyl (5-chlorobenzo[b]thiophen-3-yl)methyl(methyl)phosphinate With lithium hexamethyldisilazane in tetrahydrofuran T=-20 - 10°C; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran T=-10 - 20°C; Inert atmosphere; 3: With hydrogenchloride in tetrahydrofuran T=4°C; Product distribution / selectivity;
参考文献
JANSSEN PHARMACEUTICA NV; ANZALONE, Luigi; FEIBUSH, Penina; DORZIOTIS, Ilias, Konstantinos; LI, Xun; VILLANI, Frank, J.
Patent: WO2010/51372 A1, 2010 ;
Location in patent: Page/Page column 142 ;