5-氯吡唑并[1,5-a]嘧啶-3-羧酸乙酯合成路线 (共 3 条)
反应条件
trichlorophosphate 2 h; Reflux;
参考文献
ARRAY BIOPHARMA INC.; ALLEN, Shelley; ANDREWS, Steven S.; CONDROSKI, Kevin Ronald; HAAS, Julia; HUANG, Lily; JIANG, Yutong; KERCHER, Timothy; SEO, Jeongbeob
Patent: WO2011/6074 A1, 2011 ;
Location in patent: Page/Page column 70-71 ;
反应条件
1.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 110 °C 1.2: 20 °C / pH 4 2.1: trichlorophosphate / 2 h / Reflux View Scheme
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 110 °C 2: trichlorophosphate / 4 h / 120 °C View Scheme