2-(6-甲氧基-1-氧代-1,2,3,4-四氢萘-2-基)-2-甲基丙二酸二乙酯合成路线 （共 3 条）
反应条件
1: With potassium hydroxide in ethanol 15 h; Inert atmosphere; 2: With hydrogenchloride in ethanol; water pH=2 - 3; Inert atmosphere; 3: With triethylsilane; boron trifluoride diethyl etherate; trifluoroacetic acid in dichloromethane
参考文献
BIOGEN IDEC MA INC.; GUCKIAN, Kevin, M.; CALDWELL, Richard, D.; KUMARAVEL, Gnanasambandam; LEE, Wen-cherng; LIN, Edward, Yin-shiang; LIU, Xiaogao; MA, Bin; SCOTT, Daniel, M.; SHI, Zhan; ZHENG, Guo, Zhu; TAVERAS, Arthur, G.; THOMAS, Jermaine
Patent: WO2010/51031 A1, 2010 ;
Location in patent: Page/Page column 22-23 ;
WO 2010/051031 A1
反应条件
1: methyl malonic acid diethylester With sodium hydride in N,N-dimethyl-formamide
T=0 - 5°C; Inert atmosphere;
2: 2-bromo-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-one in N,N-dimethyl-formamide
T=-3°C; Inert atmosphere;
3: With hydrogenchloride in water; N,N-dimethyl-formamide
pH=4 - 5; Inert atmosphere;
参考文献
BIOGEN IDEC MA INC.; GUCKIAN, Kevin, M.; CALDWELL, Richard, D.; KUMARAVEL, Gnanasambandam; LEE, Wen-cherng; LIN, Edward, Yin-shiang; LIU, Xiaogao; MA, Bin; SCOTT, Daniel, M.; SHI, Zhan; ZHENG, Guo, Zhu; TAVERAS, Arthur, G.; THOMAS, Jermaine
Patent: WO2010/51031 A1, 2010 ;
Location in patent: Page/Page column 22 ;
WO 2010/051031 A1
反应条件
1: methanol
2: N,N-dimethyl-formamide
View Scheme
参考文献
Caldwell, Richard D.; GUCKIAN, Kevin M.; KUMARA VEL, Gnanasambandam; LEE, Wen-Cherng; LIN, Edward Yin-Shiang; LlU, Xiaogao; MA, Bin; SCOTT, Daniel M.; SHl, Zhan; THOMAS, Jermaine; TAVERAS, Arthur G.; ZHENG, Guo Zhu
Patent: US2014/100195 A1, 2014 ;
