3-乙氧基-2-(6-甲氧基-1,2,3,4-四氢萘-2-基)-2-甲基-3-氧代丙酸合成路线 （共 2 条）
反应条件
1: With potassium hydroxide in ethanol 15 h; Inert atmosphere; 2: With hydrogenchloride in ethanol; water pH=2 - 3; Inert atmosphere; 3: With triethylsilane; boron trifluoride diethyl etherate; trifluoroacetic acid in dichloromethane
参考文献
BIOGEN IDEC MA INC.; GUCKIAN, Kevin, M.; CALDWELL, Richard, D.; KUMARAVEL, Gnanasambandam; LEE, Wen-cherng; LIN, Edward, Yin-shiang; LIU, Xiaogao; MA, Bin; SCOTT, Daniel, M.; SHI, Zhan; ZHENG, Guo, Zhu; TAVERAS, Arthur, G.; THOMAS, Jermaine
Patent: WO2010/51031 A1, 2010 ;
Location in patent: Page/Page column 22-23 ;
WO 2010/051031 A1
反应条件
1: 2-methyl-3-ethoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-oxopropanoic acid With diphenyl phosphoryl azide; triethylamine in toluene T=100 - 110°C; 2 h; Inert atmosphere; 2: sodium trimethyl-silanolate in toluene T=0°C; Inert atmosphere;
参考文献
BIOGEN IDEC MA INC.; GUCKIAN, Kevin, M.; CALDWELL, Richard, D.; KUMARAVEL, Gnanasambandam; LEE, Wen-cherng; LIN, Edward, Yin-shiang; LIU, Xiaogao; MA, Bin; SCOTT, Daniel, M.; SHI, Zhan; ZHENG, Guo, Zhu; TAVERAS, Arthur, G.; THOMAS, Jermaine
Patent: WO2010/51031 A1, 2010 ;
Location in patent: Page/Page column 23 ;
WO 2010/051031 A1
