(S)-1-n-cbz-3-n-boc-氨基吡咯烷合成路线 （共 10 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1690 - 1694
反应条件
sodium hydroxide in tert-butyl alcohol Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 10 p. 1764 - 1773
反应条件
1: 95 percent / 10percent aq. NaOH / 2 h / 5 °C 2: 91 percent / pyridine / 2 h / 5 °C 3: 98 percent / sodium azide / dimethylformamide / 2 h / 100 °C 4: 95 percent / H2 / Raney nickel / methanol / 21.5 h / 21.5 - 25 °C / 2585.7 Torr 5: 84 percent / 1.0 N aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 10 p. 1764 - 1773
反应条件
1: 91 percent / pyridine / 2 h / 5 °C 2: 98 percent / sodium azide / dimethylformamide / 2 h / 100 °C 3: 95 percent / H2 / Raney nickel / methanol / 21.5 h / 21.5 - 25 °C / 2585.7 Torr 4: 84 percent / 1.0 N aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 10 p. 1764 - 1773
反应条件
1: 95 percent / H2 / Raney nickel / methanol / 21.5 h / 21.5 - 25 °C / 2585.7 Torr 2: 84 percent / 1.0 N aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 10 p. 1764 - 1773
反应条件
1: 98 percent / sodium azide / dimethylformamide / 2 h / 100 °C 2: 95 percent / H2 / Raney nickel / methanol / 21.5 h / 21.5 - 25 °C / 2585.7 Torr 3: 84 percent / 1.0 N aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 10 p. 1764 - 1773
反应条件
hydrogenchloride; acetic acid in methoxybenzene 0.333333 h;
参考文献
Hennessy, Edward J.; Saeh, Jamal C.; Sha, Li; MacIntyre, Terry; Wang, Haiyun; Larsen, Nicholas A.; Aquila, Brian M.; Ferguson, Andrew D.; Laing, Naomi M.; Omer, Charles A.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1690 - 1694
反应条件
hydrogenchloride in 1,4-dioxane; dichloromethane T=20°C; 2 h;
参考文献
Chaturvedula, Prasad V.; Luo, Guanglin; Vig, Shikha; Poindexter, Graham S.; Beno, Brett R,
Patent: US2004/224901 A1, 2004 ;
Location in patent: Page/Page column 11 ;
反应条件
hydrogen; palladium on activated charcoal in methanol T=21 - 25°C; P=1639.4 - 2616.8 Torr; 0.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 10 p. 1764 - 1773
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C 1.2: 19 h / 0 - 20 °C 2.1: hydrogen / 5 palladium on charcoal / ethanol; methanol / 2 h View Scheme
参考文献
WO2012/154274 A1, ;
WO 2012/154274 A1
