(R)-3-叔丁氧羰基氨基吡咯烷-1-甲酸苄酯合成路线 （共 9 条）
反应条件
triethylamine in tetrahydrofuran T=20°C; 24 h;
参考文献
Beight, Douglas Wade; Masters, John Joseph; Sawyer, Jason Scott; Shuman, Robert Theodore; Wiley, Michael Robert; Yee, Ying Kwong
Patent: US2004/10017 A1, 2004 ;
Location in patent: Page/Page column 14 ;
反应条件
triethylamine in dichloromethane T=0 - 20°C; 18 h;
参考文献
Pfizer Limited
Patent: US2007/185075 A1, 2007 ;
Location in patent: Page/Page column 23 ;
US 20070185075 A1
反应条件
1: pyridine / 2 h / 5 °C 2: sodium azide / dimethylformamide / 2 h / 100 °C 3: H2 / Raney nickel / methanol / 21.5 h / 21.5 - 25 °C / 2585.7 Torr 4: 1.0 N aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 10 p. 1764 - 1773
反应条件
1: 10percent aq. NaOH / 2 h / 5 °C 2: pyridine / 2 h / 5 °C 3: sodium azide / dimethylformamide / 2 h / 100 °C 4: H2 / Raney nickel / methanol / 21.5 h / 21.5 - 25 °C / 2585.7 Torr 5: 1.0 N aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 10 p. 1764 - 1773
反应条件
1: H2 / Raney nickel / methanol / 21.5 h / 21.5 - 25 °C / 2585.7 Torr 2: 1.0 N aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 10 p. 1764 - 1773
反应条件
1: sodium azide / dimethylformamide / 2 h / 100 °C 2: H2 / Raney nickel / methanol / 21.5 h / 21.5 - 25 °C / 2585.7 Torr 3: 1.0 N aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 10 p. 1764 - 1773
反应条件
sodium hydroxide in tert-butyl alcohol Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 10 p. 1764 - 1773
反应条件
hydrogenchloride; acetic acid in methoxybenzene 0.333333 h;
参考文献
Beight, Douglas Wade; Masters, John Joseph; Sawyer, Jason Scott; Shuman, Robert Theodore; Wiley, Michael Robert; Yee, Ying Kwong
Patent: US2004/10017 A1, 2004 ;
Location in patent: Page/Page column 14 ;
反应条件
hydrogen; palladium on activated charcoal in methanol T=21 - 25°C; P=1639.4 - 2616.8 Torr; 0.5 h;
参考文献
Sanchez; Domagala; Heifetz; Priebe; Sesnie; Trehan
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1764 - 1773
