(S)-(+)-3-羟基吡咯烷盐酸盐合成路线 (共 5 条)
反应条件
hydrogenchloride; hydrogen in methanol; water T=80°C; P=7600.51 Torr;
参考文献
Catalysis Today, , vol. 150, # 1-2 p. 22 - 27
反应条件
1: (3S)-3-Hydroxypyrrolidine hydrochloride With sodium hydroxide in tetrahydrofuran 0.333333 h; 2: formaldehyd With formic acid in tetrahydrofuran; water T=60°C; 2 h; Reflux; 3: With sodium hydroxide in tetrahydrofuran; water T=0°C; pH=Ca. 10;
参考文献
Wu; Mori; Buchwald; Bodor, Nicholas
Pharmazie, 2008 , vol. 63, # 3 p. 200 - 209
反应条件
sodium hydroxide in water
参考文献
Hoffmann-La Roche Inc.
Patent: US5977381 A1, 1999 ;
反应条件
sodium hydroxide T=5°C; 2 h;
参考文献
Cardillo, Giuliana; Gentilucci, Luca; Tolomelli, Alessandra; Calienni, Maria; Qasem, Ahmed R.; Spampinato, Santi
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 9 p. 1498 - 1502
反应条件
sodium hydroxide in water
参考文献
Hoffmann-La Roche Inc.
Patent: US5977381 A1, 1999 ;