bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; sodium 2-ethyl hexanoate in water; ethyl acetate T=20°C; 5 h; Inert atmosphereLarge scale reaction;

1: aq. NaHCO3 / acetone / 4 h / 60 °C 2: Et3N / CH2Cl2 / 0.17 h / -20 °C 3: triethyl phosphite / xylene / 11 h / Heating 4: AcOH, tetra-n-butylammonium fluoride / tetrahydrofuran / 8.5 h / 50 °C 5: Ph3P, tetrakis(triphenylphosphine)palladium, sodium 2-ethylhexanoate / ethyl acetate / 1 h / Ambient temperature View Scheme

1: Et3N / CH2Cl2 / 0.17 h / -20 °C 2: triethyl phosphite / xylene / 11 h / Heating 3: AcOH, tetra-n-butylammonium fluoride / tetrahydrofuran / 8.5 h / 50 °C 4: Ph3P, tetrakis(triphenylphosphine)palladium, sodium 2-ethylhexanoate / ethyl acetate / 1 h / Ambient temperature View Scheme

1: AcOH, tetra-n-butylammonium fluoride / tetrahydrofuran / 8.5 h / 50 °C 2: Ph3P, tetrakis(triphenylphosphine)palladium, sodium 2-ethylhexanoate / ethyl acetate / 1 h / Ambient temperature View Scheme

1: triethyl phosphite / xylene / 11 h / Heating 2: AcOH, tetra-n-butylammonium fluoride / tetrahydrofuran / 8.5 h / 50 °C 3: Ph3P, tetrakis(triphenylphosphine)palladium, sodium 2-ethylhexanoate / ethyl acetate / 1 h / Ambient temperature View Scheme