5’-苯甲酰基-2’,3’-二脱氢-3’-脱氧胸腺嘧啶合成路线 （共 38 条）
反应条件
sodium methylate in methanol Ambient temperature;
参考文献
Becouarn; Czernecki; Valery
Nucleosides and Nucleotides, 1995 , vol. 14, # 6 p. 1227 - 1232
反应条件
1: 85 percent / H2 / 10percent Pd/C / ethanol / 2 h / 1292.9 Torr 2: 85 percent / 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide / toluene / 12 h / 80 °C 3: 86 percent / 1 N aq. NaOH / 6 h / Ambient temperature View Scheme
参考文献
Palomino; Meltsner; Kessel; Horwitz
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 258 - 263
反应条件
pyridine
T=50°C; 6 h;
参考文献
Tortolani; Russell; Whiterock; Hitchcock; Ghazzouli; Martin; Mansuri; Starrett Jr.
Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 3 p. 339 - 343
反应条件
hydrogen iodide in ethylene glycol dimethyl ether
T=20°C; 8 h;
参考文献
Mustafin; Suyundukova; Gataullin; Spirikhin; Abdrakhmanov; Tolstikov
Russian Chemical Bulletin, 1997 , vol. 46, # 7 p. 1362 - 1363
反应条件
acetic acid; zinc in methanol; ethyl acetate
3.5 h; Ambient temperature;
参考文献
Chen, Bang-Chi; Quinlan, Sandra L.; Stark, Derron R.; Reid, J. Gregory; Audia, Vicki H.; et al.
Tetrahedron Letters, 1995 , vol. 36, # 44 p. 7957 - 7960
反应条件
in N,N-dimethyl-formamide
T=100°C; 6 h;
参考文献
Chen, Bang-Chi; Quinlan, Sandra L.; Reid, J. Gregory; Spector, Richard H.
Tetrahedron Letters, 1998 , vol. 39, # 8 p. 729 - 732
反应条件
dihydrogen peroxide; acetic acid in tetrahydrofuran
3 h; Ambient temperature;
参考文献
Becouarn; Czernecki; Valery
Nucleosides and Nucleotides, 1995 , vol. 14, # 6 p. 1227 - 1232
反应条件
sodium iodide in ethylene glycol dimethyl ether
20 h; Heating;
参考文献
Mustafin; Gataullin; Spirikhin; Abdrakhmanov; Tolstikov
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1784 - 1790
反应条件
sodium iodide in ethylene glycol dimethyl ether
20 h; Heating;
参考文献
Mustafin; Gataullin; Spirikhin; Abdrakhmanov; Tolstikov
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1784 - 1790
反应条件
1: N-methylmorpholine / acetone
2: 1N sodium hydroxide / H2O
3: 1.) AcCl, 3.) Zn, Cu / 1.) MeOH, 2.) CH2Cl2, 3.) MeOH
4: 91 percent / dimethylformamide / 6 h / 100 °C
View Scheme
参考文献
Chen, Bang-Chi; Quinlan, Sandra L.; Reid, J. Gregory; Spector, Richard H.
Tetrahedron Letters, 1998 , vol. 39, # 8 p. 729 - 732
