5’-苯甲酰基-2’,3’-二脱氢-3’-脱氧胸腺嘧啶合成路线 （共 38 条）
反应条件
sodium iodide in ethylene glycol dimethyl ether
38 h; Heating;
参考文献
Tolstikov, G. A.; Mustafin, A. G.; Gataullin, R. R.; Abdrakhmanov, I. B.; Plyasunova, A. G.; Pokrovskii, A. G.
Chemistry of Natural Compounds, 1993 , vol. 29, # 1 p. 113 - 115
Khimiya Prirodnykh Soedinenii, 1993 , # 1 p. 133 - 136
反应条件
1: 93 percent / pyridine / CH2Cl2 / 24 h / Ambient temperature
2: 80 percent / pyridine / 12 h
3: 98 percent / acetic acid, H2SO4 / 22 h / Ambient temperature
4: 90 percent / SnCl4 / acetonitrile / 2 h / Ambient temperature
5: 89 percent / H2SO4 / acetonitrile; H2O / 18 h / 75 °C
6: 95 percent / pyridine / 36 h / Ambient temperature
7: 60 percent / NaI / 1,2-dimethoxy-ethane / 20 h / Heating
View Scheme
参考文献
Mustafin; Gataullin; Spirikhin; Abdrakhmanov; Tolstikov
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1784 - 1790
反应条件
1: 93 percent / pyridine / CH2Cl2 / 24 h / Ambient temperature
2: 80 percent / pyridine / 12 h
3: 98 percent / acetic acid, H2SO4 / 22 h / Ambient temperature
4: 90 percent / SnCl4 / acetonitrile / 2 h / Ambient temperature
5: 89 percent / H2SO4 / acetonitrile; H2O / 18 h / 75 °C
6: 95 percent / pyridine / 36 h / Ambient temperature
7: 60 percent / NaI / 1,2-dimethoxy-ethane / 20 h / Heating
View Scheme
参考文献
Mustafin; Gataullin; Spirikhin; Abdrakhmanov; Tolstikov
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1784 - 1790
反应条件
1: 1N sodium hydroxide / H2O
2: 1.) AcCl, 3.) Zn, Cu / 1.) MeOH, 2.) CH2Cl2, 3.) MeOH
3: 91 percent / dimethylformamide / 6 h / 100 °C
View Scheme
参考文献
Chen, Bang-Chi; Quinlan, Sandra L.; Reid, J. Gregory; Spector, Richard H.
Tetrahedron Letters, 1998 , vol. 39, # 8 p. 729 - 732
反应条件
1: 80 percent / pyridine / 12 h
2: 98 percent / acetic acid, H2SO4 / 22 h / Ambient temperature
3: 90 percent / SnCl4 / acetonitrile / 2 h / Ambient temperature
4: 89 percent / H2SO4 / acetonitrile; H2O / 18 h / 75 °C
5: 95 percent / pyridine / 36 h / Ambient temperature
6: 60 percent / NaI / 1,2-dimethoxy-ethane / 20 h / Heating
View Scheme
参考文献
Mustafin; Gataullin; Spirikhin; Abdrakhmanov; Tolstikov
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1784 - 1790
反应条件
1: 98 percent / AcBr, MeOH / ethyl acetate / 1 h / Heating
2: 97 percent / Zn, AcOH / methanol; ethyl acetate / 3.5 h / Ambient temperature
View Scheme
参考文献
Chen, Bang-Chi; Quinlan, Sandra L.; Stark, Derron R.; Reid, J. Gregory; Audia, Vicki H.; et al.
Tetrahedron Letters, 1995 , vol. 36, # 44 p. 7957 - 7960
反应条件
1: 35 percent / SnCl4 / acetonitrile
2: 70 percent / H2SO4 / acetonitrile; H2O / 18 h / 75 °C
3: 91 percent / pyridine / 30 h / Ambient temperature
4: 60 percent / NaI / 1,2-dimethoxy-ethane / 20 h / Heating
View Scheme
参考文献
Mustafin; Gataullin; Spirikhin; Abdrakhmanov; Tolstikov
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1784 - 1790
反应条件
1: 1.) AcCl, 3.) Zn, Cu / 1.) MeOH, 2.) CH2Cl2, 3.) MeOH
2: 91 percent / dimethylformamide / 6 h / 100 °C
View Scheme
参考文献
Chen, Bang-Chi; Quinlan, Sandra L.; Reid, J. Gregory; Spector, Richard H.
Tetrahedron Letters, 1998 , vol. 39, # 8 p. 729 - 732
反应条件
1: 90 percent / various solvent(s) / 1 h / 115 °C
2: 98 percent / AcBr, MeOH / ethyl acetate / 1 h / Heating
3: 97 percent / Zn, AcOH / methanol; ethyl acetate / 3.5 h / Ambient temperature
View Scheme
参考文献
Chen, Bang-Chi; Quinlan, Sandra L.; Stark, Derron R.; Reid, J. Gregory; Audia, Vicki H.; et al.
Tetrahedron Letters, 1995 , vol. 36, # 44 p. 7957 - 7960
反应条件
1: 91 percent / pyridine / 30 h / Ambient temperature
2: 60 percent / NaI / 1,2-dimethoxy-ethane / 20 h / Heating
View Scheme
参考文献
Mustafin; Gataullin; Spirikhin; Abdrakhmanov; Tolstikov
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1784 - 1790
