5’-苯甲酰基-2’,3’-二脱氢-3’-脱氧胸腺嘧啶合成路线 （共 38 条）
反应条件
1: 70 percent / H2SO4 / acetonitrile; H2O / 18 h / 75 °C
2: 91 percent / pyridine / 30 h / Ambient temperature
3: 60 percent / NaI / 1,2-dimethoxy-ethane / 20 h / Heating
View Scheme
参考文献
Mustafin; Gataullin; Spirikhin; Abdrakhmanov; Tolstikov
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1784 - 1790
反应条件
1: m-chloroperbenzoic acid / CH2Cl2 / 2 h / 0 °C
2: 4-picoline / xylene / 4 h / Heating
View Scheme
参考文献
Kawakami, Hiroshi; Ebata, Takashi; Koseki, Koshi; Matsumoto, Katsuya; Matsushita, Hajime; et al.
Heterocycles, 1991 , vol. 32, # 12 p. 2451 - 2470
反应条件
4-Methylpyridine in xylene
4 h; Heating; Yield given. Yields of byproduct given;
参考文献
Kawakami, Hiroshi; Ebata, Takashi; Koseki, Koshi; Matsumoto, Katsuya; Matsushita, Hajime; et al.
Heterocycles, 1991 , vol. 32, # 12 p. 2451 - 2470
反应条件
1: 82 percent / BzONa / dimethylformamide / Heating
2: 93 percent / HI / 1,2-dimethoxy-ethane / 8 h / 20 °C
View Scheme
参考文献
Mustafin; Suyundukova; Gataullin; Spirikhin; Abdrakhmanov; Tolstikov
Russian Chemical Bulletin, 1997 , vol. 46, # 7 p. 1362 - 1363
反应条件
1: 98 percent / acetic acid, H2SO4 / 22 h / Ambient temperature
2: 90 percent / SnCl4 / acetonitrile / 2 h / Ambient temperature
3: 89 percent / H2SO4 / acetonitrile; H2O / 18 h / 75 °C
4: 95 percent / pyridine / 36 h / Ambient temperature
5: 60 percent / NaI / 1,2-dimethoxy-ethane / 20 h / Heating
View Scheme
参考文献
Mustafin; Gataullin; Spirikhin; Abdrakhmanov; Tolstikov
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1784 - 1790
反应条件
1: 90 percent / SnCl4 / acetonitrile / 2 h / Ambient temperature
2: 89 percent / H2SO4 / acetonitrile; H2O / 18 h / 75 °C
3: 95 percent / pyridine / 36 h / Ambient temperature
4: 60 percent / NaI / 1,2-dimethoxy-ethane / 20 h / Heating
View Scheme
参考文献
Mustafin; Gataullin; Spirikhin; Abdrakhmanov; Tolstikov
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1784 - 1790
反应条件
1: 95 percent / pyridine / 36 h / Ambient temperature
2: 60 percent / NaI / 1,2-dimethoxy-ethane / 20 h / Heating
View Scheme
参考文献
Mustafin; Gataullin; Spirikhin; Abdrakhmanov; Tolstikov
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1784 - 1790
反应条件
1: 89 percent / H2SO4 / acetonitrile; H2O / 18 h / 75 °C
2: 95 percent / pyridine / 36 h / Ambient temperature
3: 60 percent / NaI / 1,2-dimethoxy-ethane / 20 h / Heating
View Scheme
参考文献
Mustafin; Gataullin; Spirikhin; Abdrakhmanov; Tolstikov
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1784 - 1790
反应条件
1: 96 percent / dimethylformamide / 1 h / 140 °C
2: 88 percent / AcOH, 30percent H2O2 / tetrahydrofuran / 3 h / Ambient temperature
View Scheme
参考文献
Becouarn; Czernecki; Valery
Nucleosides and Nucleotides, 1995 , vol. 14, # 6 p. 1227 - 1232
反应条件
1: 86 percent / PPh3, diisopropyl azodicarboxylate / dimethylformamide / 0.75 h / Ambient temperature
2: 96 percent / dimethylformamide / 1 h / 140 °C
3: 88 percent / AcOH, 30percent H2O2 / tetrahydrofuran / 3 h / Ambient temperature
View Scheme
参考文献
Becouarn; Czernecki; Valery
Nucleosides and Nucleotides, 1995 , vol. 14, # 6 p. 1227 - 1232
