N-(p-羟基苯乙基)-n-(2-溴-5-羟基-4-甲氧基苄基)甲酰胺合成路线 （共 13 条）
反应条件
bromine in ethanol; 2-methoxy-ethanol T=-20°C; 0.75 h;
参考文献
Sanochemia Pharmazeutica
Patent: US6369238 B1, 2002 ;
Location in patent: Example 9 ;
参考文献
Czollner, Laszlo; Frantsits, Werner; Kueenburg, Bernhard; Hedenig, Ursula; Froehlich, Johannes; Jordis, Ulrich
Tetrahedron Letters, 1998 , vol. 39, # 15 p. 2087 - 2088
反应条件
2: NaBH4 3: 90 percent View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 15 p. 2087 - 2088
反应条件
1: 92 percent / Br2 / methanol 2: 83 percent / conc. H2SO4 4: NaBH4 5: 90 percent View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 15 p. 2087 - 2088
反应条件
1: sulfuric acid / 6 h / 90 °C / |Inert atmosphere; |Large scale 2: ethanol / 4 h / |Reflux; |Large scale 3: sodium hydroxide; sodium tetrahydroborate / water / 1 h / 20 °C / |Large scale 4: formic acid / 1,4-dioxane; N,N-dimethyl-formamide / 10 h / |Reflux; |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 3, # 6 p. 425 - 431
反应条件
1: methanol / 1.) molecular sieves, r.t., overnight 2: sodium borohydride / methanol / 3 h / Ambient temperature 3: 80 percent / formic acid / Heating 4: 85 percent / bromine / CHCl3; methanol / warm up from -65 deg C to 0 deg C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1809 - 1811
反应条件
1: methanol / 1.) molecular sieves, r.t., overnight 2: sodium borohydride / methanol / 3 h / Ambient temperature 3: 80 percent / formic acid / Heating 4: 85 percent / bromine / CHCl3; methanol / warm up from -65 deg C to 0 deg C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1809 - 1811
反应条件
1: 80 percent / formic acid / Heating 2: 85 percent / bromine / CHCl3; methanol / warm up from -65 deg C to 0 deg C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1809 - 1811
反应条件
1: sodium borohydride / methanol / 3 h / Ambient temperature 2: 80 percent / formic acid / Heating 3: 85 percent / bromine / CHCl3; methanol / warm up from -65 deg C to 0 deg C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1809 - 1811
反应条件
1.1: potassium hexacyanoferrate(III); potassium carbonate / toluene / 1 h / 50 - 60 °C / |Large scale 2.1: toluene-4-sulfonic acid / toluene / |Reflux; |Large scale 3.1: lithium aluminium tetrahydride; hydrogen / tetrahydrofuran / 3 h / 60 - 65 °C / |Inert atmosphere; |Large scale 3.2: 0.25 h / |Large scale 3.3: 0.33 h / 60 °C / pH < 1 / |Large scale 4.1: triethylamine / ethanol / |Reflux; |Large scale View Scheme
参考文献
Kueenburg, Bernhard; Czollner, Laszlo; Frohlich, Johannes; Jordis, Ulrich
Organic Process Research and Development, 1999 , vol. 3, # 6 p. 425 - 431
