N-(p-羟基苯乙基)-n-(2-溴-5-羟基-4-甲氧基苄基)甲酰胺合成路线 （共 13 条）
反应条件
1.1: potassium hexacyanoferrate(III); potassium carbonate / toluene / 1 h / 50 - 60 °C / |Large scale 2.1: toluene-4-sulfonic acid / toluene / |Reflux; |Large scale 3.1: lithium aluminium tetrahydride; hydrogen / tetrahydrofuran / 3 h / 60 - 65 °C / |Inert atmosphere; |Large scale 3.2: 0.25 h / |Large scale 3.3: 0.33 h / 60 °C / pH < 1 / |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 3, # 6 p. 425 - 431
反应条件
sodium carbonate; potassium hexacyanoferrate(III) in water; toluene
参考文献
Czollner, Laszlo; Frantsits, Werner; Kueenburg, Bernhard; Hedenig, Ursula; Froehlich, Johannes; Jordis, Ulrich
Tetrahedron Letters, 1998 , vol. 39, # 15 p. 2087 - 2088
反应条件
1.1: potassium hexacyanoferrate(III); potassium carbonate / toluene / 1 h / 50 - 60 °C / |Large scale 2.1: toluene-4-sulfonic acid / toluene / |Reflux; |Large scale 3.1: lithium aluminium tetrahydride; hydrogen / tetrahydrofuran / 3 h / 60 - 65 °C / |Inert atmosphere; |Large scale 3.2: 0.25 h / |Large scale 3.3: 0.33 h / 60 °C / pH < 1 / |Large scale 4.1: triethylamine / ethanol / |Reflux; |Large scale 5.1: L-Selectridereg; / tetrahydrofuran / 3.5 h / |Inert atmosphere; |Large scale 5.2: 0.5 h / 20 °C / |Large scale View Scheme
参考文献
Kueenburg, Bernhard; Czollner, Laszlo; Frohlich, Johannes; Jordis, Ulrich
Organic Process Research and Development, 1999 , vol. 3, # 6 p. 425 - 431
