Pd-BaSO4; hydrogen in pyridine P=760.051 Torr; 1.5 h;

T=195°C;

N,N,N',N',N'',N''-hexamethylphosphoric triamide; n-butyllithium; carbon dioxide; potassium hydride Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

1: 50 percent / CH3SO2Cl, LiCl, s-collidine / dimethylformamide / 0 °C 2: 70 percent / DCC, DMAP / CH2Cl2 / Ambient temperature View Scheme