(1R,4S)-rel-4-[[2-氨基-6-氯-5-[(4-氯苯基)偶氮]-4-嘧啶基]氨基]-2-环戊烯-1-甲醇合成路线 （共 6 条）
反应条件
1: Et3N / butan-1-ol / 48 h / Heating 2: 1.) 3 N HCl, sodium nitrite, 2.) sodium acetate trihydrate / 1.) water, 2.) acetic acid, water, RT, overnight View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 1 p. 17 - 21
反应条件
1: 0.5 N aq. barium hydroxide / Heating; overnight 2: Et3N / butan-1-ol / 48 h / Heating 3: 1.) 3 N HCl, sodium nitrite, 2.) sodium acetate trihydrate / 1.) water, 2.) acetic acid, water, RT, overnight View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 1 p. 17 - 21
反应条件
hydrogenchloride; sodium acetate; sodium nitrite 1.) water, 2.) acetic acid, water, RT, overnight; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 1 p. 17 - 21
反应条件
1: 66 percent / Zn, acetic acid / H2O; ethanol / 3 h / Heating 2: 81 percent / sodium nitrite, acetic acid / H2O / 1 h / 0 °C 3: 83 percent / liquid ammonia / methanol / 20 h / 60 °C View Scheme
参考文献
Vince; Hua
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 17 - 21
反应条件
1: 66 percent / Zn, acetic acid / H2O; ethanol / 3 h / Heating 2: 81 percent / sodium nitrite, acetic acid / H2O / 1 h / 0 °C 3: 90 percent / 0.25 N aq. NaOH / 3 h / Heating View Scheme
参考文献
Vince; Hua
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 17 - 21
反应条件
acetic acid; zinc in ethanol; water 3 h; Heating;
参考文献
Vince; Hua
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 17 - 21
