(5R)-1-甲基-5-乙烯基-2-吡咯烷酮合成路线 （共 3 条）
反应条件
1: (COCl)2, DMSO / CH2Cl2 / 0.5 h / -78 °C 2: tetrahydrofuran; hexane / 1.) -78 deg C, 4 h, 2.) from -78 deg C to rt, overnight View Scheme
参考文献
Williams, Peter D.; Perlow, Debra S.; Payne, Linda S.; Holloway, M. Katharine; Siegl, Peter K. S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 887 - 900
反应条件
1: 75 percent / LAH / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) from -78 deg C to rt, 1.5 h 2: (COCl)2, DMSO / CH2Cl2 / 0.5 h / -78 °C 3: tetrahydrofuran; hexane / 1.) -78 deg C, 4 h, 2.) from -78 deg C to rt, overnight View Scheme
参考文献
Williams, Peter D.; Perlow, Debra S.; Payne, Linda S.; Holloway, M. Katharine; Siegl, Peter K. S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 887 - 900
反应条件
in tetrahydrofuran; hexane 1.) -78 deg C, 4 h, 2.) from -78 deg C to rt, overnight; Yield given;
参考文献
Williams, Peter D.; Perlow, Debra S.; Payne, Linda S.; Holloway, M. Katharine; Siegl, Peter K. S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 887 - 900
