(1R,2S)-2-氨基-1-环戊烷羧酸合成路线 （共 40 条）
反应条件
hydrogen; triethylamine; 10percent Pd(OH)2/C in ethanol T=40°C; P=760.051 Torr; 3 h;
参考文献
Aggarwal, Varinder K; Roseblade, Stephen; Alexander, Rikki
Organic and biomolecular chemistry, 2003 , vol. 1, # 4 p. 684 - 691
反应条件
lipase acrylic resin from Candida antarctica in di-isopropyl ether; water T=60°C; 264 h;
参考文献
US2007/32514 A1, ;
Page/Page column 18 ;
US 20070032514 A1
反应条件
immobilized lipase B from Candida antarctica; water in di-isopropyl ether T=60°C; 249 h;
参考文献
Organic letters, , vol. 5, # 8 p. 1209 - 1212
反应条件
1: 85 percent / LiOH*H2O / tetrahydrofuran / 4 h / 70 °C 2: PdCl2(CH3CN)2 / acetone / 1 h / 65 °C 3: 1.16 g / NaHCO3 / acetone / 16 h / 20 °C 4: 50 percent / H2 / 10percent Pd/C / acetic acid / 48 h / 40 °C / 5320.36 Torr 5: 85 percent / H2; Et3N / 10percent Pd(OH)2/C / ethanol / 3 h / 40 °C / 760.05 Torr View Scheme
参考文献
Organic and biomolecular chemistry, , vol. 1, # 4 p. 684 - 691
反应条件
1: PdCl2(CH3CN)2 / acetone / 1 h / 65 °C 2: 1.16 g / NaHCO3 / acetone / 16 h / 20 °C 3: 50 percent / H2 / 10percent Pd/C / acetic acid / 48 h / 40 °C / 5320.36 Torr 4: 85 percent / H2; Et3N / 10percent Pd(OH)2/C / ethanol / 3 h / 40 °C / 760.05 Torr View Scheme
参考文献
Organic and biomolecular chemistry, , vol. 1, # 4 p. 684 - 691
反应条件
1: 50 percent / H2 / 10percent Pd/C / acetic acid / 48 h / 40 °C / 5320.36 Torr 2: 85 percent / H2; Et3N / 10percent Pd(OH)2/C / ethanol / 3 h / 40 °C / 760.05 Torr View Scheme
参考文献
Organic and biomolecular chemistry, , vol. 1, # 4 p. 684 - 691
反应条件
methylamine in ethanol 1.5 h; Ambient temperature;
参考文献
Theil, Fritz; Ballschuh, Sibylle
Tetrahedron Asymmetry, 1996 , vol. 7, # 12 p. 3565 - 3572
反应条件
hydrogenchloride in water
参考文献
Evans, Chris; McCague, Ray; Roberts, Stanley M.; Sutherland Alan G.; Wisdom, Richard
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 9 p. 2276 - 2277
反应条件
water in di-isopropyl ether T=60°C; 240 h; Inert atmosphereEnzymatic reaction;
参考文献
Lengyel, George A.; Frank, Rebecca C.; Horne, W. Seth
Journal of the American Chemical Society, 2011 , vol. 133, # 12 p. 4246 - 4249
反应条件
1: quinine / toluene; CCl4 / 60 h / -55 °C 2: triethylamine / tetrahydrofuran / 1 h / -20 °C 3: NaN3 / tetrahydrofuran; H2O / -10 - 20 °C 4: benzene / 2 h / Heating 5: triethylamine / CH2Cl2 / 4 h / Heating 6: 98 percent / H2 / Pd/C / methanol / 20 °C View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 14, # 22 p. 3455 - 3468
