(1R,2S)-2-氨基-1-环戊烷羧酸合成路线 （共 40 条）
反应条件
1: 95 percent / pyridine / Ambient temperature 2: 36 percent / KH2PO4, K2HPO4, water / acetone / 12 h / Ambient temperature; lipase PS "Amano" 3: 93 percent / HgCl2, CaCO3, water / acetonitrile / 7 h / Heating 4: benzene 5: benzene / 3 h / Heating 6: H2, AcOH / 10percent Pd/C / 18 h / 760 Torr / Ambient temperature 7: Et3N / tetrahydrofuran; benzene / 1 h / Ambient temperature 8: 91 percent / NaIO4, KMnO4, KH2PO4, K2HPO4 / H2O; acetone / 3 h / Ambient temperature 9: 80 percent / 4 N HCl in dioxane / 1 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 41, # 6 p. 1012 - 1018
反应条件
1: 93 percent / HgCl2, CaCO3, water / acetonitrile / 7 h / Heating 2: benzene 3: benzene / 3 h / Heating 4: H2, AcOH / 10percent Pd/C / 18 h / 760 Torr / Ambient temperature 5: Et3N / tetrahydrofuran; benzene / 1 h / Ambient temperature 6: 91 percent / NaIO4, KMnO4, KH2PO4, K2HPO4 / H2O; acetone / 3 h / Ambient temperature 7: 80 percent / 4 N HCl in dioxane / 1 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 41, # 6 p. 1012 - 1018
反应条件
1: H2, AcOH / 10percent Pd/C / 18 h / 760 Torr / Ambient temperature 2: Et3N / tetrahydrofuran; benzene / 1 h / Ambient temperature 3: 91 percent / NaIO4, KMnO4, KH2PO4, K2HPO4 / H2O; acetone / 3 h / Ambient temperature 4: 80 percent / 4 N HCl in dioxane / 1 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 41, # 6 p. 1012 - 1018
反应条件
hydrogenchloride 1 h; Ambient temperature;
参考文献
Konosu; Oida
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 6 p. 1012 - 1018
反应条件
trifluoroacetic acid 16 h; Ambient temperature;
参考文献
Davies, Stephen G.; Ichihara, Osamu; Lenoir, Isabelle; Walters, Iain A. S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 11 p. 1411 - 1416
反应条件
1: 95 percent / H2 / Pd/C / ethyl acetate 2: 95 percent / HCl / H2O View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 9 p. 2276 - 2277
反应条件
trifluoroacetic acid T=0°C; 2 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 56, # 23 p. 6644 - 6655
反应条件
morpholine; palladium diacetate; triphenylphosphine in ethanol
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 3 p. 433 - 436
反应条件
1: 44 percent / NaBH4 / ethanol / 1 h / -30 - -20 °C 2: 89 percent / imidazole / tetrahydrofuran / 4.5 h / Ambient temperature 3: 38 percent / Pseudomonas cepacia lipase / various solvent(s) / 4 h 4: 92 percent / Wofatit SBW (OH-) / methanol / 24 h / Ambient temperature 5: 70 percent / DEAD, Ph3P / tetrahydrofuran 6: 95 percent / aq. AcOH / tetrahydrofuran / Ambient temperature 7: 80 percent / CrO3, H2SO4 / acetone / 0.5 h / Ambient temperature 8: 91 percent / aq. MeNH2 / ethanol / 1.5 h / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 7, # 12 p. 3565 - 3572
反应条件
1: 89 percent / imidazole / tetrahydrofuran / 4.5 h / Ambient temperature 2: 38 percent / Pseudomonas cepacia lipase / various solvent(s) / 4 h 3: 92 percent / Wofatit SBW (OH-) / methanol / 24 h / Ambient temperature 4: 70 percent / DEAD, Ph3P / tetrahydrofuran 5: 95 percent / aq. AcOH / tetrahydrofuran / Ambient temperature 6: 80 percent / CrO3, H2SO4 / acetone / 0.5 h / Ambient temperature 7: 91 percent / aq. MeNH2 / ethanol / 1.5 h / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 7, # 12 p. 3565 - 3572
