(1R,2S)-2-氨基-1-环戊烷羧酸合成路线 （共 40 条）
反应条件
1: 92 percent / Wofatit SBW (OH-) / methanol / 24 h / Ambient temperature 2: 70 percent / DEAD, Ph3P / tetrahydrofuran 3: 95 percent / aq. AcOH / tetrahydrofuran / Ambient temperature 4: 80 percent / CrO3, H2SO4 / acetone / 0.5 h / Ambient temperature 5: 91 percent / aq. MeNH2 / ethanol / 1.5 h / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 7, # 12 p. 3565 - 3572
反应条件
1: 70 percent / DEAD, Ph3P / tetrahydrofuran 2: 95 percent / aq. AcOH / tetrahydrofuran / Ambient temperature 3: 80 percent / CrO3, H2SO4 / acetone / 0.5 h / Ambient temperature 4: 91 percent / aq. MeNH2 / ethanol / 1.5 h / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 7, # 12 p. 3565 - 3572
反应条件
1: 80 percent / CrO3, H2SO4 / acetone / 0.5 h / Ambient temperature 2: 91 percent / aq. MeNH2 / ethanol / 1.5 h / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 7, # 12 p. 3565 - 3572
反应条件
1: 95 percent / aq. AcOH / tetrahydrofuran / Ambient temperature 2: 80 percent / CrO3, H2SO4 / acetone / 0.5 h / Ambient temperature 3: 91 percent / aq. MeNH2 / ethanol / 1.5 h / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 7, # 12 p. 3565 - 3572
反应条件
1: 2.) 2,6-di-tert-butylphenol / 1.) toluene, -78 deg C, 2.) THF, -78 deg C to room temperature, 30 min 2: 75 percent / 1.) H2, 2.) HCl / 1.) Pd-C / 1.) AcOH, 50 deg C, 4 bar, 2.) MeOH 3: 95 percent / TFA / 16 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 11 p. 1411 - 1416
反应条件
1: 1.) LDA, I2, 2.) DBU / 1.) THF, -78 deg C, 1.5 h, 2.) 0 deg C, 1 h, room temperature, 48 h 2: 2.) 2,6-di-tert-butylphenol / 1.) toluene, -78 deg C, 2.) THF, -78 deg C to room temperature, 30 min 3: 75 percent / 1.) H2, 2.) HCl / 1.) Pd-C / 1.) AcOH, 50 deg C, 4 bar, 2.) MeOH 4: 95 percent / TFA / 16 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 11 p. 1411 - 1416
反应条件
1: 91 percent / NaIO4, KMnO4, KH2PO4, K2HPO4 / H2O; acetone / 3 h / Ambient temperature 2: 80 percent / 4 N HCl in dioxane / 1 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 41, # 6 p. 1012 - 1018
反应条件
1: 75 percent / 1.) H2, 2.) HCl / 1.) Pd-C / 1.) AcOH, 50 deg C, 4 bar, 2.) MeOH 2: 95 percent / TFA / 16 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 11 p. 1411 - 1416
反应条件
1.1: dichloromethane / 0 - 40 °C / Inert atmosphere 1.2: 36 h 2.1: water / di-isopropyl ether / 240 h / 60 °C / Inert atmosphere; Enzymatic reaction View Scheme
参考文献
Journal of the American Chemical Society, , vol. 133, # 12 p. 4246 - 4249
反应条件
Candida antarctica lipase B; water T=70°C; 120 h;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 8 p. 1005 - 1009
