1-Boc-吡咯烷-3-甲酸甲酯合成路线 （共 30 条）
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
参考文献
Boto, Alicia; Hernandez, Rosendo; De Leon, Yolanda; Murguia, Jose R.; Rodriguez-Afonso, Abigail
European Journal of Organic Chemistry, 2005 , # 4 p. 673 - 682
反应条件
hydrogen; nickel in methanol T=20°C; P=760 Torr; 24 h;
参考文献
Tishkov, Alexander A.; Reissig, Hans-Ulrich; Ioffe, Sema L.
Synlett, 2002 , # 6 p. 863 - 866
参考文献
Boga, Sobhana B.; Alhassan, Abdul-Basit; Cooper, Alan B.; Shih, Neng-Yang; Doll, Ronald J.
Tetrahedron Letters, 2009 , vol. 50, # 38 p. 5315 - 5316
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane T=0°C; 13 h;
参考文献
WO2004/14910 A1, ;
Page 69-70 ;
WO 2004/014910 A1
反应条件
1: 1-benzyl-pyrrolidine-3-carboxylic acid methyl ester; 1-chloroethyl chlorocarbonate in 1,2-dichloro-ethane T=20°C; 0.5 h; 2: With methanol 0.333333 h; Heating / reflux; 3: di-tert-butyl dicarbonate With triethylamine in chloroform T=20°C; 16 h;
参考文献
US2003/229226 A1, ;
Page 16-17 ;
反应条件
in dichloromethane T=20°C; 16 h;
参考文献
MacLeod; Baker; Freedman; Patel; Merchant; Roe; Saunders
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 2052 - 2059
反应条件
in methanol; hexane; toluene T=0 - 20°C; 0.166667 h;
参考文献
WO2008/153858 A1, ;
Page/Page column 221 ;
WO 2008/153858 A1
反应条件
triethylamine in dichloromethane T=22°C;
参考文献
Mendiola, Javier; Garcia-Cerrada, Susana; De Frutos, Oscar; De La Puente, Maria Luz; Gu, Rui Lin; Khau, Vien V.
Organic Process Research and Development, 2009 , vol. 13, # 2 p. 292 - 296
反应条件
1: 70 percent / 9-borabicyclo[3.3.1]nonane (BBN) / tetrahydrofuran / Heating 2: 92 percent / H2 / 10 wt percent Pd/C / ethyl acetate View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 673 - 682
反应条件
1: 99 percent / methanol / Heating 2: 70 percent / 9-borabicyclo[3.3.1]nonane (BBN) / tetrahydrofuran / Heating 3: 92 percent / H2 / 10 wt percent Pd/C / ethyl acetate View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 673 - 682
