1: 1H-imidazole; iodine; triphenylphosphine / toluene; acetonitrile / 16 h / 65 °C 2: acetonitrile / 16 h / 80 °C View Scheme
参考文献
Davies, Stephen G.; Fletcher, Ai M.; Hughes, Deri G.; Lee, James A.; Price, Paul D.; Roberts, Paul M.; Russell, Angela J.; Smith, Andrew D.; Thomson, James E.; Williams, Oliver M.H.
Tetrahedron, 2011 , vol. 67, # 51 p. 9975 - 9992
1.1: 1H-imidazole; iodine; triphenylphosphine / toluene; acetonitrile / 16 h / 65 °C
2.1: silver tetrafluoroborate / acetonitrile / 16 h / 80 °C
3.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C
4.2: -78 - 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 - 20 °C
5.2: 16 h / 20 °C
6.1: 20 wt. Pd(OH)2 on activated carbon; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr
View Scheme
参考文献
Davies, Stephen G.; Fletcher, Ai M.; Hughes, Deri G.; Lee, James A.; Price, Paul D.; Roberts, Paul M.; Russell, Angela J.; Smith, Andrew D.; Thomson, James E.; Williams, Oliver M.H.
Tetrahedron, 2011 , vol. 67, # 51 p. 9975 - 9992
1.1: 1H-imidazole; iodine; triphenylphosphine / toluene; acetonitrile / 16 h / 65 °C
2.1: silver tetrafluoroborate / acetonitrile / 16 h / 80 °C
3.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C
4.2: -78 - 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 - 20 °C
5.2: 16 h / 20 °C
6.1: 20 wt. Pd(OH)2 on activated carbon; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr
View Scheme
参考文献
Davies, Stephen G.; Fletcher, Ai M.; Hughes, Deri G.; Lee, James A.; Price, Paul D.; Roberts, Paul M.; Russell, Angela J.; Smith, Andrew D.; Thomson, James E.; Williams, Oliver M.H.
Tetrahedron, 2011 , vol. 67, # 51 p. 9975 - 9992
With 1H-imidazole; iodine; triphenylphosphine in acetonitrile T=80°C; 16 h;
参考文献
Davies, Stephen G.; Hughes, Deri G.; Price, Paul D.; Roberts, Paul M.; Russell, Angela J.; Smith, Andrew D.; Thomson, James E.; Williams, Oliver M.H. Synlett, 2010 , # 4 art. no. D34409ST, p. 567 - 570
With 1H-imidazole; iodine; triphenylphosphine in toluene; acetonitrile T=65°C; 2 h;
参考文献
Davies, Stephen G.; Hughes, Deri G.; Price, Paul D.; Roberts, Paul M.; Russell, Angela J.; Smith, Andrew D.; Thomson, James E.; Williams, Oliver M.H. Synlett, 2010 , # 4 art. no. D34409ST, p. 567 - 570
Multi-step reaction with 4 steps 1.1: 1H-imidazole; iodine; triphenylphosphine / toluene; acetonitrile / 16 h / 65 °C2.1: silver tetrafluoroborate / acetonitrile / 16 h / 80 °C3.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C4.2: -78 - 20 °C
参考文献
Davies, Stephen G.; Fletcher, Ai M.; Hughes, Deri G.; Lee, James A.; Price, Paul D.; Roberts, Paul M.; Russell, Angela J.; Smith, Andrew D.; Thomson, James E.; Williams, Oliver M.H. Tetrahedron, 2011 , vol. 67, # 51 p. 9975 - 9992
Multi-step reaction with 5 steps 1.1: 1H-imidazole; iodine; triphenylphosphine / toluene; acetonitrile / 16 h / 65 °C2.1: silver tetrafluoroborate / acetonitrile / 16 h / 80 °C3.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C4.2: -78 - 20 °C5.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 - 20 °C5.2: 16 h / 20 °C
参考文献
Davies, Stephen G.; Fletcher, Ai M.; Hughes, Deri G.; Lee, James A.; Price, Paul D.; Roberts, Paul M.; Russell, Angela J.; Smith, Andrew D.; Thomson, James E.; Williams, Oliver M.H. Tetrahedron, 2011 , vol. 67, # 51 p. 9975 - 9992
