2-氟-3-(四氢吡喃-4-基)吡啶合成路线 （共 3 条）
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C;
参考文献
AMGEN INC.; ALLEN, Jennifer; FROHN, Michael; HARRINGTON, Paul; PICKRELL, Alexander; RZASA, Robert; SHAM, Kelvin; HU, Essa
Patent: WO2011/143366 A1, 2011 ;
Location in patent: Page/Page column 42 ;
WO 2011/143366 A1
反应条件
1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / Inert atmosphere; Reflux 2: hydrogen / palladium on activated charcoal / methanol / 20 °C View Scheme
参考文献
AMGEN INC.; ALLEN, Jennifer; FROHN, Michael; HARRINGTON, Paul; PICKRELL, Alexander; RZASA, Robert; SHAM, Kelvin; HU, Essa
Patent: WO2011/143366 A1, 2011 ;
WO 2011/143366 A1
反应条件
1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / Inert atmosphere; Reflux 2: hydrogen / palladium on activated charcoal / methanol / 20 °C View Scheme
参考文献
AMGEN INC.; ALLEN, Jennifer; FROHN, Michael; HARRINGTON, Paul; PICKRELL, Alexander; RZASA, Robert; SHAM, Kelvin; HU, Essa
Patent: WO2011/143366 A1, 2011 ;
WO 2011/143366 A1
