1: 2,4-dihydroxy-6-methylpyridine With phosphorus oxytribromide in N,N-dimethyl-formamide T=110°C; 1 h; 2: With water in N,N-dimethyl-formamide T=20 - 25°C; 3: sodium difluoromonochloroacetate
参考文献
AstraZeneca AB
Patent: US2010/125087 A1, 2010 ;
Location in patent: Page/Page column 18 ;
US 20100125087 A1
