1: 4-chloromethylphenyl methyl sulphone With chloro-trimethyl-silane; zinc in N,N-dimethyl-formamide; isopropyl alcohol T=20 - 45°C; Large scale; 2: tert-butyl (6-fluoro-3-methyl-4-trifluoromethanesulfonyloxynaphthalen-2-yl)acetate With [Pd(PPh3)2Cl2] in N,N-dimethyl-formamide; isopropyl alcohol T=45 - 95°C; Negishi Coupling; Large scale; Temperature;