反应条件
1: di-tert-butyl 2,6-diazaspiro[3.3]heptane-2,6-dicarboxylate With methanol; acetyl chloride T=20°C; 20 h; Inert atmosphere; 2: With potassium hydroxide in methanol T=30°C; 3: oxalic acid in diethyl ether T=20°C; 1 h;
参考文献
MERCK FROSST CANADA LTD.; LACHANCE, Nicolas; LEGER, Serge; OBALLA, Renata, M.; POWELL, David; TRANMER, Geoffrey, K.; MARTINS, Evelyn; GAREAU, Yves
Patent: WO2010/108268 A1, 2010 ;
Location in patent: Page/Page column 69 ;
WO 2010/108268 A1
