1-甲基-5-氧代-D-脯氨酸甲酯合成路线 （共 4 条）
反应条件
potassium carbonate in acetonitrile T=80°C; 72 h;
参考文献
ASTRAZENECA AB
Patent: US2011/92526 A1, 2011 ;
Location in patent: Page/Page column 22 ;
反应条件
1: SOCl2 / 6 h / -20 °C 2: 1.) Na / 1.) toluene, -20 deg C, 2.) toluene, DMF, RT, overnight View Scheme
参考文献
Tetrahedron, , vol. 52, # 38 p. 12357 - 12372
反应条件
sodium hydride 1.) DMF, mineral oil, rt, 8 h, 2.) 0 deg C, overnight; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 3 p. 887 - 900
反应条件
1: 75 percent / LAH / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) from -78 deg C to rt, 1.5 h 2: (COCl)2, DMSO / CH2Cl2 / 0.5 h / -78 °C 3: tetrahydrofuran; hexane / 1.) -78 deg C, 4 h, 2.) from -78 deg C to rt, overnight View Scheme
参考文献
Williams, Peter D.; Perlow, Debra S.; Payne, Linda S.; Holloway, M. Katharine; Siegl, Peter K. S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 887 - 900
