1: With triethylamine; LDH-PdOsW T=70°C; Heck reaction; 16 h; 2: With 4-methyl-morpholine; (DHQD)2PHAL; dihydrogen peroxide; LDH-PdOsW in tert-butyl alcohol T=20°C; 1 h; Further stages.;

1,4-bis(9-O-dihydroquinidine)phthalazine in water; tert-butyl alcohol T=20°C; 10 h;

potassium dioxotetrahydroxoosmate(VI); potassium carbonate; potassium hexacyanoferrate(III); methanesulfonamide; DHQD-PHAL-OPEG-OMe in water; tert-butyl alcohol T=20°C; 30 h; Title compound not separated from byproducts;

hydrogen fluoride in acetonitrile T=20°C; Substitution; 6 h;

1: Et3N / Na2PdCl4/K2OsO4*2H2O/layered double-hydroxides(Mg-Al-Cl) / 70 °C 2: Et3N; (DHQD)2PHAL; N-methylmorpholine N-oxide / Na2PdCl4/K2OsO4*2H2O/layered double-hydroxides(Mg-Al-Cl) / 2-methyl-propan-2-ol; H2O / 20 °C View Scheme

1: With triethylamine; NAP-Mg-PdOs in acetonitrile T=70°C; tandem Heck reaction; 2: With (3a,9R,3'''a,4'"b,9'"R)-9,9'-[1,4-phthalazinediylbis(oxy)]bis[6'-(methyloxy)-10,11-dihydrocinchonan]; 4-methylmorpholine N-oxide in water; tert-butyl alcohol T=20°C; Title compound not separated from byproducts;

1: With tin(IV) chloride; N-ethyl-N,N-diisopropylamine in dichloromethane T=-78 - -70°C; 0.5 h; 2: With acetyl chloride in methanol; dichloromethane T=20°C; 1 h; Further stages. Title compound not separated from byproducts.;

1: styrene; (3aS,4R,7S,7aR)-3-acryloyl-4,8,8-trimethylhexahydro-3H-4,7-methano-1,2,3-benzoxathiazole 2,2-dioxide With copper(l) chloride; Grubbs-Hoveyda ruthenium catalyst in ethyl acetate Heating; 2: With sodium periodate; cerium(III) chloride; tetrabutylammonium (meta)periodate in various solvents T=0°C; 3: methanol With methylmagnesium bromide in tetrahydrofuran; dichloromethane T=0°C; Further stages. Title compound not separated from byproducts.;

1: styrene; Oppolzer’s sultam acrylamide With copper(l) chloride; Grubbs-Hoveyda ruthenium catalyst in ethyl acetate Heating; 2: With sodium periodate; cerium(III) chloride; tetrabutylammonium (meta)periodate in various solvents T=0°C; 3: methanol With methylmagnesium bromide in tetrahydrofuran; dichloromethane T=0°C; Further stages. Title compound not separated from byproducts.;

methanol; acetyl chloride in dichloromethane T=20°C; 1 h;