1: 89 percent / NaOH / methanol; H2O / 7 h / Ambient temperature 2: DCC, DMAP / CH2Cl2 / 1.) 0 deg C, 2h, 2.) r.t., 16 h 3: 97 percent / NaOH / H2O; methanol / 4 h / Heating 4: 98 percent / KHCO3 / dimethylformamide / 12 h / Ambient temperature View Scheme

Multi-step reaction with 2 steps 1: 89 percent / NaOH / methanol; H2O / 7 h / Ambient temperature2: DCC, DMAP / CH2Cl2 / 1.) 0 deg C, 2h, 2.) r.t., 16 h  

Multi-step reaction with 4 steps 1: 89 percent / NaOH / methanol; H2O / 7 h / Ambient temperature2: DCC, DMAP / CH2Cl2 / 1.) 0 deg C, 2h, 2.) r.t., 16 h3: 97 percent / NaOH / H2O; methanol / 4 h / Heating4: 98 percent / KHCO3 / dimethylformamide / 12 h / Ambient temperature