6-溴-2-氟-3-吡啶甲醇合成路线 （共 1 条）
反应条件
1: 2-bromo-6-fluoro-pyridine With n-butyllithium; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; hexane T=-78 - 0°C; 3 h; 2: formaldehyd in tetrahydrofuran; hexane T=20°C; 3: With water in tetrahydrofuran; hexane
参考文献
F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; DO, Steven; HU, Huiyong; KOLESNIKOV, Aleksandr; TSUI, Vickie, H.; WANG, Xiaojing
Patent: WO2014/1377 A1, 2014 ;
Location in patent: Page/Page column 145; 146 ;
