2-氯-3-氟吡啶-4-胺合成路线 （共 2 条）
反应条件
1: With trifluoroacetic acid in dichloromethane T=20°C; 5 h; 2: in methanol; dichloromethane
参考文献
F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; ELLWOOD, Charles; GOODACRE, Simon; LAI, Yingjie; LIANG, Jun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong
Patent: WO2012/35039 A1, 2012 ;
Location in patent: Page/Page column 97 ;
WO 2012/035039 A1
反应条件
1.1: diphenyl phosphoryl azide / toluene / 3 h / 110 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C 2.2: NH2 cartridge View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; ELLWOOD, Charles; GOODACRE, Simon; LAI, Yingjie; LIANG, Jun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong
Patent: WO2012/35039 A1, 2012 ;
WO 2012/035039 A1
