3-羟基-4-戊酸叔丁酯合成路线 （共 14 条）
反应条件
N-((R)-N-diphenylmethyl-2-amino-2-phenylethyl)-(S)-prolinol; BrZnCH2CO2-t-Bu in tetrahydrofuran 5 h; Heating; Product distribution;
参考文献
Choi, Eui Ta; Lee, Min Hee; Kim, Yongtae; Park, Yong Sun
Tetrahedron, 2008 , vol. 64, # 7 p. 1515 - 1522
反应条件
N-((R)-N-diphenylmethyl-2-amino-2-phenylethyl)-(S)-prolinol; chloro-trimethyl-silane; bromoacetic acid tert-butyl ester; zinc in tetrahydrofuran 2.5 h; Refluxkinetic resolution; KineticsReactivity; Reagent/catalystTime; optical yield given as percent eeenantioselective reaction;
参考文献
Min, Hee Lee; Eui, Ta Choi; Kim, Dajung; Yoon, Min Lee; Yong, Sun Park
European Journal of Organic Chemistry, 2008 , # 33 p. 5630 - 5637
反应条件
chromium(VI) oxide; sulfuric acid in water; acetone
Ambient temperature;
参考文献
Zibuck, Regina; Streiber, Jeanne M.
Journal of Organic Chemistry, 1989 , vol. 54, # 19 p. 4717 - 4719
反应条件
Jone's reagent in acetone
T=20°C; 1 h; Cooling with ice; Overall yield = 97 percent; Overall yield = 165 mg;
参考文献
Stergiou, Anastasios; Bariotaki, Anna; Kalaitzakis, Dimitris; Smonou, Ioulia
Journal of Organic Chemistry, 2013 , vol. 78, # 14 p. 7268 - 7273
