8-(4-氟苯基)-1,4-二噁螺[4.5]-7-癸烯合成路线 （共 6 条）
反应条件
toluene-4-sulfonic acid in toluene
参考文献
Bristol-Myers Squibb Co.
Patent: US5352678 A1, 1994 ;
US 5352678 A
反应条件
sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether T=80°C;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2004/83218 A1, 2004 ;
Location in patent: Page 50 ;
反应条件
1.1: magnesium / tetrahydrofuran / |Reflux 1.2: 20 °C / |Reflux 2.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / 0 - 80 °C View Scheme
参考文献
Zhou, Lin; Liu, Xiaohua; Ji, Jie; Zhang, Yuheng; Hu, Xiaolei; Lin, Lili; Feng, Xiaoming
Journal of the American Chemical Society, 2012 , vol. 134, # 49 p. 20208 - 20208
反应条件
1.1: magnesium / tetrahydrofuran / |Reflux 1.2: 20 °C / |Reflux 2.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / 0 - 80 °C View Scheme
参考文献
Zhou, Lin; Liu, Xiaohua; Ji, Jie; Zhang, Yuheng; Hu, Xiaolei; Lin, Lili; Feng, Xiaoming
Journal of the American Chemical Society, 2012 , vol. 134, # 41 p. 17023 - 17026
反应条件
1.1: magnesium / tetrahydrofuran / |Reflux 1.2: 24 h / |Reflux 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / pyridine / 2.5 h / 0 - 80 °C View Scheme
参考文献
Zhou, Lin; Liu, Xiaohua; Ji, Jie; Zhang, Yuheng; Hu, Xiaolei; Lin, Lili; Feng, Xiaoming
Journal of the American Chemical Society, 2012 , vol. 134, # 49 p. 20208 - 20208
反应条件
1: palladium 10 on activated carbon; hydrogen / methanol; ethyl acetate / 20 °C
2: hydrogenchloride / tetrahydrofuran; water / Reflux
View Scheme
参考文献
Zhou, Lin; Liu, Xiaohua; Ji, Jie; Zhang, Yuheng; Hu, Xiaolei; Lin, Lili; Feng, Xiaoming
Journal of the American Chemical Society, 2012 , vol. 134, # 49 p. 20208 - 20208
