6-溴-4-羟基-3-喹啉羧酸乙酯合成路线 （共 9 条）
反应条件
in diphenylether T=250°C; 0.0833333 h; microwave irradiation;
参考文献
WO2009/40377 A2, ;
Page/Page column 19 ;
反应条件
1: 1 h / Heating 2: various solvent(s) / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 22 p. 6443 - 6450
反应条件
1: 1 h / Heating 2: various solvent(s) / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 22 p. 6443 - 6450
反应条件
Gould-Jacob reaction; 0.233333 h; Irradiation;
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 41, # 3 p. 650 - 652
反应条件
1: aqueous KOH 2: diphenyl ether 3: acetic acid; bromine View Scheme
参考文献
Schofield; Swain
Journal of the Chemical Society, 1950 , p. 384,389
反应条件
trichlorophosphate in N,N-dimethyl-formamide T=20°C; 3 h; Inert atmosphere;
参考文献
ELI LILLY AND COMPANY
Patent: US2012/184577 A1, 2012 ;
Location in patent: Page/Page column 2; 3 ;
反应条件
1: aqueous KOH 2: diphenyl ether 3: phosphoryl chloride / 135 °C View Scheme
参考文献
INTELLIKINE, LLC; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; CAMPBELL, Simon, Fraser
Patent: WO2012/116237 A2, 2012 ;
WO 2012/116237 A2
反应条件
1: aqueous KOH 2: diphenyl ether View Scheme
参考文献
INTELLIKINE, LLC; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; CAMPBELL, Simon, Fraser
Patent: WO2012/116237 A2, 2012 ;
WO 2012/116237 A2
反应条件
1: aqueous KOH
2: diphenyl ether
3: acetic acid; acetic acid anhydride; sulfuryl chloride
View Scheme
参考文献
Schofield; Swain
Journal of the Chemical Society, 1950 , p. 384,389
