1: 3-[5,6-bis(methyloxy)-2-pyridinyl]-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,2-d]pyrimidine-6-carboxylic acid With N-ethyl-N,N-diisopropylamine; HATU in N,N-dimethyl-formamide 0.5 h; 2: 4-chloro-benzylamine in N,N-dimethyl-formamide T=20°C;