(5aR,6aR,7aS)-六氢-3,3-二甲基-3H,5H-环丙烷并[d]恶唑并[3,4-a]吡啶-5-酮合成路线 （共 2 条）
反应条件
dirhodium tetraacetate in dichloromethane T=25°C;
参考文献
GLAXO GROUP LIMITED; DI FABIO, Romano
Patent: WO2012/89606 A1, 2012 ;
Location in patent: Page/Page column 34-35 ;
WO 2012/089606 A1
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 1.2: 0 °C 2.1: triethylamine / tetrahydrofuran; methanol / 5.25 h / 2 - 5 °C 3.1: toluene-4-sulfonic acid / toluene / 1.5 h / 25 - 85 °C 4.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 20 °C 5.1: sodium nitrite / dichloromethane; water / 3 h / 2 - 3 °C / pH 5 / Aqueous buffer 6.1: dirhodium tetraacetate / dichloromethane / 3 h / 25 °C View Scheme
参考文献
GLAXO GROUP LIMITED; DI FABIO, Romano
Patent: WO2012/89607 A1, 2012 ;
WO 2012/089607 A1
