2-甲氧基-4-(4-甲基哌嗪-1-基)苯胺合成路线 （共 5 条）
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2: hydrogen / palladium 10 on activated carbon / ethanol / 2 h View Scheme
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2: hydrogen / palladium 10 on activated carbon / ethanol / 2 h View Scheme
反应条件
1: potassium carbonate / acetone / 4 h / |Reflux 2: potassium carbonate / dimethyl sulfoxide / 20 °C 3: iron; ammonium chloride / tetrahydrofuran; water / 3 h / |Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 77, p. 75 - 83
反应条件
1: trifluoroacetic acid / Sec-butyl alcohol / 100 °C 2: platinum(IV) oxide; hydrogen / methanol 3: N-ethyl-N,N-diisopropylamine / dichloromethane View Scheme
参考文献
Han, Chun; Wan, Ledong; Ji, Hongbin; Ding, Ke; Huang, Zhangjian; Lai, Yisheng; Peng, Sixun; Zhang, Yihua
European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 75 - 83
反应条件
tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tert-butyl alcohol T=100°C;
参考文献
Deng, Xianming; Yang, Qingkai; Kwiatkowski, Nicholas; Sim, Taebo; McDermott, Ultan; Settleman, Jeffrey E.; Lee, Jiing-Dwan; Gray, Nathanael S.
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 3 p. 195 - 200
