N-Cbz-4-羟甲基哌啶合成路线 (共 20 条)
反应条件
triethylamine in dichloromethane T=0°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 1 p. 380 - 382
参考文献
NEUROSEARCH A/S
Patent: WO2007/93603 A1, 2007 ;
Location in patent: Page/Page column 15 ;
WO 2007/093603 A1
反应条件
triethylamine in dichloromethane; dimethyl sulfoxide
参考文献
Fang, Xinqin; Garvey, David S.; Gaston, Ricky D.; Lin, Chia-En; Ranatunga, Ramani R.; Richardson, Stewart K.; Wang, Tiansheng; Wang, Weiheng; Wey, Shiow-Jyi
Patent: US2003/203915 A1, 2003 ;
反应条件
sodium hydroxide in dichloromethane
参考文献
Merck and Co., Inc.
Patent: US6265434 B1, 2001 ;
US 6265434 B1
反应条件
triethylamine in dichloromethane T=0°C;
参考文献
Zhersh, Sergey; Buryanov, Volodymyr V.; Karpenko, Oleksandr V.; Grygorenko, Oleksandr O.; Tolmachev, Andrey A.
Synthesis, 2011 , # 22 art. no. Z72611SS, p. 3669 - 3674
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane T=20°C; 5 h;
参考文献
Ueno, Hiroshi; Yokota, Katsuyuki; Hoshi, Jun-Ichi; Yasue, Katsutaka; Hayashi, Mikio; Hase, Yasunori; Uchida, Itsuo; Aisaka, Kazuo; Katoh, Susumu; Cho, Hidetsura
Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3586 - 3604
反应条件
triphenylphosphine in dichloromethane
参考文献
Japan Tobacco Inc.
Patent: US6562828 B1, 2003 ;
US 6562828 B1
反应条件
1: pyridinium chlorochromate / dichloromethane / 20 °C 2: trifluoroacetic acid / dichloromethane 3: sodium tetrahydroborate / methanol 4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran 5: palladium 10 on activated carbon; hydrogen / ethanol View Scheme
参考文献
Qi, Xian Liang; Yang, Er Qun; Zhang, Jun Tao; Wang, Tao; Cao, Xiao Ping
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 661 - 664
反应条件
1: pyridinium chlorochromate / dichloromethane / 20 °C 2: trifluoroacetic acid / dichloromethane 3: sodium tetrahydroborate / methanol View Scheme
参考文献
Qi, Xian Liang; Yang, Er Qun; Zhang, Jun Tao; Wang, Tao; Cao, Xiao Ping
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 661 - 664
反应条件
1: pyridinium chlorochromate; Celite / CH2Cl2 / 20 °C
2: tetrahydrofuran / -78 °C
3: pyridinium chlorochromate; Celite / CH2Cl2 / 20 °C
View Scheme
参考文献
Chang, Meng-Yang; Kung, Yung-Hua; Ma, Chih-Chong
Tetrahedron Letters, 2007 , vol. 48, # 2 p. 199 - 202