7,8-二氢-2-甲氧基-1,6-萘啶-5(6h)-酮合成路线 （共 4 条）
反应条件
in 1,4-dioxane T=110°C; 0.5 h; Inert atmosphereMicrowave irradiation;
参考文献
F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; CHEN, Wenming; HORNSPERGER, Benoit; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander V.; MOHR, Peter; TAN, Xuefei; WANG, Zhanguo; ZHOU, Mingwei
Patent: WO2013/79452 A1, 2013 ;
Location in patent: Page/Page column 139 ;
反应条件
1: 2,6-di-tert-butyl-4-methyl-phenol; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere 2: ammonia / methanol / 24 h / 100 °C / Sealed vessel View Scheme
参考文献
Conn, P. Jeffrey; Lindsley, Craig W.; Stauffer, Shaun R.; Manka, Jason; Jacobs, Jon; Zhou, Ya; Bartolomé-Nebreda, José Manuel; Macdonald, Gregor James; Conde-Ceide, Susana; Jones, Carrie K.
Patent: US2012/172391 A1, 2012 ;
US 20120172391 A1
反应条件
1: thionyl chloride / 5 h / 80 °C / Industry scale 2: 1 h / 20 °C / Industry scale 3: 2,6-di-tert-butyl-4-methyl-phenol; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere 4: ammonia / methanol / 24 h / 100 °C / Sealed vessel View Scheme
参考文献
Conn, P. Jeffrey; Lindsley, Craig W.; Stauffer, Shaun R.; Manka, Jason; Jacobs, Jon; Zhou, Ya; Bartolomé-Nebreda, José Manuel; Macdonald, Gregor James; Conde-Ceide, Susana; Jones, Carrie K.
Patent: US2012/172391 A1, 2012 ;
US 20120172391 A1
反应条件
1.1: potassium tert-butylate / 48 h / 80 °C 1.2: pH 1 2.1: thionyl chloride / 5 h / 80 °C / Industry scale 3.1: 1 h / 20 °C / Industry scale 4.1: 2,6-di-tert-butyl-4-methyl-phenol; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere 5.1: ammonia / methanol / 24 h / 100 °C / Sealed vessel View Scheme
参考文献
Conn, P. Jeffrey; Lindsley, Craig W.; Stauffer, Shaun R.; Manka, Jason; Jacobs, Jon; Zhou, Ya; Bartolomé-Nebreda, José Manuel; Macdonald, Gregor James; Conde-Ceide, Susana; Jones, Carrie K.
Patent: US2012/172391 A1, 2012 ;
US 20120172391 A1
