1-Boc-3-氟哌啶-3-羧酸乙酯合成路线 （共 3 条）
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.333333 h; 2: With 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in tetrahydrofuran T=-78 - 20°C; 2.25 h;
参考文献
MITHRIDION, INC.; ABRAHAM, Brent, D.; COPP, Richard, R.; FARNHAM, James, G.; HANSON, Seth, A.; HENDRICKSON, Michael, L.; OCKULY, Jeffrey, C.; TWOSE, Trevor, M.; VERDONE, Melinda, L.
Patent: WO2012/33956 A1, 2012 ;
Location in patent: Page/Page column 160 ;
WO 2012/033956 A1
反应条件
1.1: triethylamine / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0 - 20 °C 2.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -78 °C 2.2: 2.25 h / -78 - 20 °C View Scheme
参考文献
MITHRIDION, INC.; ABRAHAM, Brent, D.; COPP, Richard, R.; FARNHAM, James, G.; HANSON, Seth, A.; HENDRICKSON, Michael, L.; OCKULY, Jeffrey, C.; TWOSE, Trevor, M.; VERDONE, Melinda, L.
Patent: WO2012/33956 A1, 2012 ;
WO 2012/033956 A1
反应条件
1.1: triethylamine / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0 - 20 °C 2.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -78 °C 2.2: 2.25 h / -78 - 20 °C View Scheme
参考文献
MITHRIDION, INC.; ABRAHAM, Brent, D.; COPP, Richard, R.; FARNHAM, James, G.; HANSON, Seth, A.; HENDRICKSON, Michael, L.; OCKULY, Jeffrey, C.; TWOSE, Trevor, M.; VERDONE, Melinda, L.
Patent: WO2012/33956 A1, 2012 ;
WO 2012/033956 A1
