[4'-[3-甲基-4-[[[((R)-1-苯基乙基)氧基]羰基]氨基]异恶唑-5-基]联苯-4-基]乙酸合成路线 （共 7 条）
反应条件
1: With water; lithium hydroxide hydrate in methanol T=20°C; 2: in methanol; water Acidic conditions;
参考文献
AMIDRA PHARMACEUTICALS, INC.; BRITTAIN, Jason, Edward; SEIDERS, Thomas, Jon; KING, Christopher, David
Patent: WO2011/159550 A2, 2011 ;
Location in patent: Page/Page column 80 ;
WO 2011/159550 A2
反应条件
1: dimethylsulfide borane complex; (S)-Corey-Bakshi-Shibata reagent / tetrahydrofuran / 0.25 h / 0 - 20 °C 2: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 75 °C 3: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethylene glycol dimethyl ether; water / 90 °C / Inert atmosphere 4: water; lithium hydroxide hydrate / methanol / 20 °C View Scheme
参考文献
AMIDRA PHARMACEUTICALS, INC.; BRITTAIN, Jason, Edward; SEIDERS, Thomas, Jon; KING, Christopher, David
Patent: WO2011/159550 A2, 2011 ;
WO 2011/159550 A2
反应条件
1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 6 h / 80 °C 2: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethylene glycol dimethyl ether; water / 90 °C / Inert atmosphere 3: water; lithium hydroxide hydrate / methanol / 20 °C View Scheme
参考文献
AMIDRA PHARMACEUTICALS, INC.; BRITTAIN, Jason, Edward; SEIDERS, Thomas, Jon; KING, Christopher, David
Patent: WO2011/159550 A2, 2011 ;
WO 2011/159550 A2
反应条件
1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 75 °C 2: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethylene glycol dimethyl ether; water / 90 °C / Inert atmosphere 3: water; lithium hydroxide hydrate / methanol / 20 °C View Scheme
参考文献
AMIDRA PHARMACEUTICALS, INC.; BRITTAIN, Jason, Edward; SEIDERS, Thomas, Jon; KING, Christopher, David
Patent: WO2011/159550 A2, 2011 ;
WO 2011/159550 A2
反应条件
1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethylene glycol dimethyl ether; water / 90 °C / Inert atmosphere 2: water; lithium hydroxide hydrate / methanol / 20 °C View Scheme
参考文献
AMIDRA PHARMACEUTICALS, INC.; BRITTAIN, Jason, Edward; SEIDERS, Thomas, Jon; KING, Christopher, David
Patent: WO2011/159550 A2, 2011 ;
WO 2011/159550 A2
反应条件
1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 75 °C 2: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethylene glycol dimethyl ether; water / 90 °C / Inert atmosphere 3: water; lithium hydroxide hydrate / methanol / 20 °C View Scheme
参考文献
AMIDRA PHARMACEUTICALS, INC.; BRITTAIN, Jason, Edward; SEIDERS, Thomas, Jon; KING, Christopher, David
Patent: WO2011/159550 A2, 2011 ;
WO 2011/159550 A2
反应条件
sodium hydroxide in ethanol Industry scale;
参考文献
WO2011/159550 A2, ;
Page/Page column 85-86 ;
WO 2011/159550 A2
