1-(2,3-二氟苯基)乙醇合成路线 (共 2 条)
反应条件
methanol; sodium tetrahydroborate T=20°C; 0.5 h;
参考文献
AMIRA PHARMACEUTICALS, INC.
Patent: US2010/152257 A1, 2010 ;
Location in patent: Page/Page column 26 ;
US 20100152257 A1
反应条件
1: With C28H36ClMnN2O2; potassium acetate in dichloromethane; water 0.0833333 h; 2: With N-bromosuccinmide in dichloromethane; water T=20°C; 4 h; Kinetics; enantioselective reaction;
参考文献
Xu, Daqian; Wang, Shoufeng; Shen, Zhiqiang; Xia, Chungu; Sun, Wei
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 14 p. 2730 - 2732