N-甲基-Nalpha-{[(2-甲基-2-丙基)氧基]羰基}-L-色氨酰胺合成路线 （共 3 条）
反应条件
1,1'-carbonyldiimidazole 1.) CH2Cl2, -10 deg C, 2.) 0 deg C; Yield given. Multistep reaction;
参考文献
Kortylewicz; Galardy
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 263 - 273
反应条件
1,1'-carbonyldiimidazole 1.) THF, RT, 2 h, 2.) THF, RT, 24 h; Yield given. Multistep reaction;
参考文献
Levy, Daniel E.; Lapierre, France; Liang, Weisheng; Ye, Wenqing; Lange, Christopher W.; Li, Xiaoyuan; Grobelny, Damian; Casabonne, Marie; Tyrrell, David; Holme, Kevin; Nadzan, Alex; Galardy, Richard E.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 2 p. 199 - 223
反应条件
1: 100 percent / 4 N HCl / dioxane; methanol / 4 h / Ambient temperature 2: 1.) CDI, 2.) Et3N / 1.) THF, RT, 2 h, 2.) THF, RT 3: KOH, HONH2*HCl / methanol / Ambient temperature View Scheme
参考文献
Levy, Daniel E.; Lapierre, France; Liang, Weisheng; Ye, Wenqing; Lange, Christopher W.; Li, Xiaoyuan; Grobelny, Damian; Casabonne, Marie; Tyrrell, David; Holme, Kevin; Nadzan, Alex; Galardy, Richard E.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 2 p. 199 - 223
