3-(1H-苯并[d]咪唑-2-基)哌啶-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
1: tert-butyl 3-((2-aminophenyl)carbamoyl)piperidine-1-carboxylate With hydrogenchloride in water T=50 - 60°C; 3 h; 2: di-tert-butyl dicarbonate With triethylamine in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran
参考文献
WO2013/84241 A1, ;
Page/Page column 21 ;
反应条件
T=120°C; neat (no solvent);
参考文献
Lavrador-Erb, Karine; Ravula, Satheesh Babu; Yu, Jinghua; Zamani-Kord, Said; Moree, Wilna J.; Petroski, Robert E.; Wen, Jianyun; Malany, Siobhan; Hoare, Samuel R.J.; Madan, Ajay; Crowe, Paul D.; Beaton, Graham
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 9 p. 2916 - 2919
反应条件
1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C 2: hydrogenchloride / water / 3 h / 50 - 60 °C View Scheme
反应条件
1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C 2: hydrogenchloride / water / 3 h / 50 - 60 °C View Scheme
