n-butyllithium; Zinc chloride; tetrakis (triphenylphosphine) palladium (0) in tetrahydrofuran; diethyl ether; hexane

sodium methylate in methanol; water; ethyl acetate

1: 2,6-Dibromopyridine With n-butyllithium in tetrahydrofuran Dehalogenation; 2: With zinc(II) chloride in diethyl ether T=20°C; Metallation; 3: 2-bromo-4-methyl-pyrimidine With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; diethyl ether Substitution; 2 h; Heating;

1.1: 80 percent / phosphorus tribromide 2.1: n-BuLi / tetrahydrofuran 2.2: ZnCl2 / diethyl ether / 20 °C 2.3: 35 percent / Pd(PPh3)4 / tetrahydrofuran; diethyl ether / 2 h / Heating View Scheme

1.1: 70 percent / phosphorus oxychloride 2.1: 80 percent / phosphorus tribromide 3.1: n-BuLi / tetrahydrofuran 3.2: ZnCl2 / diethyl ether / 20 °C 3.3: 35 percent / Pd(PPh3)4 / tetrahydrofuran; diethyl ether / 2 h / Heating View Scheme